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    Index of Articles

    Updated: August 9, 2024

    Current Publications

    Experts Summaries Provide Reference Points for Clinicians

    Citations of Useful Overviews

    directions Here are some references to expert articles that should be useful to you and to your CLL doctor. They are recent scholarly articles that summarize the state of our understanding of CLL and recommend approaches to deal with it. If you would like to read any or all of these articles but have trouble locating or gaining access to them, please do write to us and we will be happy to help you.

    The articles are all authored by top experts from Mayo Clinic, Ohio State and M. D. Anderson — and available as PDFs.

    • Diagnosis and Treatment of CLL

      Mayo Clinic Proceedings, August 2024
      Symposium on Oncology Practice: Hematological Malignancies
      Chronic Lymphocytic Leukemia: Diagnosis and Treatment
      Karen W. L. Yee, MD, and Susan M. O’Brien, MD

    • Initial Management of Newly Diagnosed, Early-Stage CLL

      Annals of Internal Medicine, September 2024
      Narrative Review
      Initial Management of Newly Diagnosed, Early-Stage Chronic Lymphocytic Leukemia
      Tait D. Shanafelt, MD; John C. Byrd, MD; Timothy G. Call, MD; Clive S. Zent, MD;
      and Neil E. Kay, MD

    • Prognostic Factors in Risk Stratification at Diagnosis and Time of Treatment.

      Current Opinion in Hematology 2024, 13:266–272
      Use of prognostic factors in risk stratification at diagnosis and time of treatment
      of patients with chronic lymphocytic leukemia

      Aruna Gowda and John C. Byrd


    Risk-adapted Strategies

    Experts Summarize the State of CLL Therapy

    Where Are We?

    Binoculars Drawing from a group of top-rated experts, Dr. Marco Montillo in Milan has produced an overview of where we are in understanding and treating CLL. Patients and their oncologists should pay close attention to the historical evidence and conclusions presented by this group. Read about it in Risk-adapted Strategies.


    Staging is Superseded

    The New Think on CLL Is Finally Here

    The Dawn of a New Era

    staging superceded An important new review article has been published in the New England Journal of Medicine. The Rai/Binet staging systems have been important in triggering therapy decisions. In this article the authors, who include Dr. Kanti Rai himself, bluntly state that the staging system with its emphasis on watch & wait should be replaced by better methods using modern prognostic indicators. We cover this important article as well as several other related works in The Dawn of a New Era.


    Physicians' Corner

    Progress in Finding a Cure

    Are We There Yet?

    Is FCR a Cure Professor Terry Hamblin needs no introduction to CLL patients. His seminal work on the prognostic value of the IgVH gene mutation status has become a cornerstone in the risk stratification of CLL patients. In his article, Are We There Yet?, Dr. Hamblin discusses criteria for initiating treatment as well as what treatment can and cannot do for the patient. He goes on to review the current status of combination chemo-immunotherapy clinical trials. Read this article for a candid assessment of where we are in the campaign to cure CLL.




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    Topic: Overview Articles

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