 |
|
|
|
|
|
|
|
|
|
|
 |
|
|||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|
||
 |
 |
 |
|
|||||||
 |
|
|||||||||
 |
|
|||||||||
Alert Number 14
Date: April 18, 2024
The conventional wisdom used to be that CLL is an incurable disease and that there is no point in trying to mop up the last remaining cancer cell in the patient's body. How things have changed in the last few years! If a patient is in CR remission after therapy but still has some cancer left behind, should we treat the patient again almost right away while he is still in remission, to try and get rid of the last bit of the cancer? This is the hot new frontier of CLL clinical trials. Many researchers are tacking a "consolidation" phase at the tail end of a full-fledged therapy regime, to see if the one-two punch can take the tumor kill all the way to completion. The popular RPC combo trial from the ECOG study group (Ohio State and other locations) has added a Campath chaser after full-course RPC therapy.
But what about the downsides? Trust me, there are always downsides to consider - there is no free lunch in the cancer business. The latest article on our website discusses the potential downsides of Campath consolidation therapy following quickly upon the heels of primary therapy with conventional chemotherapy. We review and discuss the details of two pivotal clinical trials reports that have just been published in the last couple of months. The results from both trials are sobering and may give you cause for concern. Once again, it becomes very clear that CLL patients need to make risk-adapted, individualized, prognostic-based therapy decisions. In this game, it is what you do not know that will come back to bite you.
Be well, stay informed.
Chaya
_____
NOTICE: This page from the Topics Alert archive was originally emailed to subscribers of Topics Alert, a free service of CLL Topics Inc. If you are not a subscriber and you wish to receive email Alerts, please register at the Topics Alert subscription page. The content of this page is intended for information only and it is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.
———
Disclaimer: The content of this website is intended for information only and is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.
Copyright Notice:
Copyright © 2024-2007 CLL Topics, Inc. All Rights Reserved.
All materials contained on this site are protected by United States copyright law and may not be reproduced, distributed, transmitted, displayed, published or broadcast without the prior written permission of CLL Topics, Inc. You may not alter or remove any trademark, copyright or other notice from copies of the content.
However, you may download and print material from CLLTopics.org exclusively for your personal, noncommercial use.
———
