 |
|
|
|
|
|
|
|
|
|
|
 |
|
|||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|
||
 |
 |
 |
|
|||||||
 |
|
|||||||||
 |
|
|||||||||
Alert Number 44
Date: September 29, 2024
I am happy to report, the light at the end of the tunnel is getting brighter (and it is NOT an approaching train).
Several recent research articles have opened up exciting new opportunities in the treatment of CLL. These feature new small molecule drugs that take an entirely different approach to targeting CLL cells. These are not your father's chemotherapy drugs, most of which target the nuclear DNA of cells, with the unavoidable risk of mutagenicity. Nor are they bulky (and expensive!) monoclonal antibodies like Rituxan and Campath, which have a hard time dealing with bulky lymph nodes and bone marrow - to some degree because it is hard for these "fat ladies" to get into all the nooks and crannies of bone marrow and lymph nodes. Small molecules like the ones we discuss below are more likely to reach all these hard-to-reach parts.
Here is the best part: in this new approach to treating CLL: it seems to make no difference if you are IgVH mutated or unmutated, CD38 positive or not, chemo-naïve or have been through the wars with every chemotherapy drug known to man. In fact, there are some indications that heavily pretreated and late Rai stage patients may respond better to this approach! How is that for a change? Rejoice all ye Bucket C folks!
You can read all about these developments in Target Mitochondrion. I sense a buzz in the research community - I would not be surprised if we start seeing some of these drugs in clinical trials as early as 2024.
Be well,
Chaya
_____
NOTICE: This page from the Topics Alert archive was originally emailed to subscribers of Topics Alert, a free service of CLL Topics Inc. If you are not a subscriber and you wish to receive email Alerts, please register at the Topics Alert subscription page. The content of this page is intended for information only and it is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.
———
Disclaimer: The content of this website is intended for information only and is NOT meant to be medical advice. Please be sure to consult and follow the advice of your doctors on all medical matters.
Copyright Notice:
Copyright © 2024-2007 CLL Topics, Inc. All Rights Reserved.
All materials contained on this site are protected by United States copyright law and may not be reproduced, distributed, transmitted, displayed, published or broadcast without the prior written permission of CLL Topics, Inc. You may not alter or remove any trademark, copyright or other notice from copies of the content.
However, you may download and print material from CLLTopics.org exclusively for your personal, noncommercial use.
———
